Transformation and cytotoxicity of iron in siderosis bulbi.
نویسنده
چکیده
Ocular tissues from two enucleated and one trabeculectomized human eyes with siderosis bulbi were studied by electron microscopy. Ferritin particles were demonstrated in various cell types of the three eyes. Other types of iron were not identifiable. The ferritin particles were scattered throughout the cytoplasm, with a few particles in the nucleus and extracellular space. More ferritin particles were seen in tissues near the iron foreign body. The cells which contained numerous ferritin particles also had siderosomes, most of which were thought to be conglomerates of the ferritin particles in the secondary lysosomes. Cells with numerous ferritin particles, particularly in the siderosomes, showed vacuolar degeneration. The present study indicated that in siderosis bulbi, iron released from the iron foreign body is deposited as ferritin scattered throughout the cytoplasm and is sometimes accumulated as siderosomes, in the affinitive cells. In siderosis bulbi, the cells become damaged by the deposition of ferritin in the cytoplasm, especially in the form of siderosomes.
منابع مشابه
Non-recordable electroretinogram in siderosis bulbi might not indicate poor visual outcome.
Purpose: to report a case of Siderosis Bulbi that attained a good postoperative visual outcome despite of non-recordable Electroretinogram.
متن کاملOcular Trauma Score in Siderosis Bulbi With Retained Intraocular Foreign Body.
The purpose of this study was to investigate the clinical characteristic and visual outcome of siderosis bulbi with retained intraocular foreign body (IOFB) and to validate the predictive value of the Ocular Trauma Score (OTS) in siderosis bulbi. Certain numerical values rendered to the OTS variables at present were summated (Table 1) and converted into 5 OTS categories as performed in the OTS ...
متن کامل[Siderosis bulbi. Clinical presentation of a case of three years from onset].
CASE REPORT The clinical and functional characteristics of a 30 years-old patient with three years-evolution siderosis bulbi are described in this paper, as well as the treatment using phacoemulsification and vitrectomy for the elimination of the metallic remains. DISCUSSION In spite of the fact that the majority of the intraocular foreign bodies (IOFB) have a dangerous immediate effect, in c...
متن کاملIron-containing corneal rust rings treated with desferrioxamine.
INJURY to the cornea with an iron-containing foreign body usually leaves a rust ring. Most surgeons advise complete removal of any rust, but this often causes considerable trauma to the already injured cornea. Desferrioxamine ("Desferal", Ciba Laboratories) is an iron-free compound isolated from a strain of Streptomycespilosus, which binds ferric ions to form an octahedral complex ferrioxamine....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Investigative ophthalmology & visual science
دوره 27 2 شماره
صفحات -
تاریخ انتشار 1986